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dc.contributor.authorMelicher, Dóra
dc.contributor.authorIllés, Anett
dc.contributor.authorLittvay, Levente
dc.contributor.authorTárnoki, Ádám Domonkos
dc.contributor.authorTárnoki, Dávid László
dc.contributor.authorBikov, András
dc.contributor.authorKunos, László
dc.contributor.authorCsabán, Dóra
dc.contributor.authorBuzás, Irén Edit
dc.contributor.authorMolnár, Judit Mária
dc.contributor.authorFalus, András
dc.date.available2022-03-29T09:33:51Z
dc.date.issued2019
dc.identifier.doihttp://dx.doi.org/10.5114/aoms.2019.83173
dc.identifier.urihttp://hdl.handle.net/20.500.14018/13385
dc.description.abstractRecent experimental and population studies have highlighted the existence of telomere-mitochondria interplay. Besides studies revealing the molecular mechanisms underlying the associations of telomere defects and mitochondrial functions, investigations of mitochondrial DNA copy number (mtDNAcn) and telomere length (TL) in healthy and disease phenotypes have likewise begun, with the aim of gaining more insights about their relationship in humans. A total of 142 asymptomatic adult twins, comprising 96 monozygotic (MZ) and 46 dizygotic (DZ) twins (mean age: 50.54 ±15.43 years), members of the Hungarian Twin Registry, were included in the analysis. Applying the qPCR standard curve method, we investigated the relationship of mtDNA copy number, telomere length and clinical data, besides assessing co-twin similarities of MZ and DZ twins for their mtDNAcn and TL measures. We found that twins were similar in their intraclass correlation coefficients irrespective of zygosity, suggesting a possibly more important role of common (shared) environmental factors compared to non-shared (unique) environmental and to a smaller degree also individual genetic influences. We confirmed a significant positive association between mtDNAcn and TL (r = 0.28, p < 0.01) in age- and sex-corrected analysis. Following bivariate estimates and correction with significant predictors, the independent positive associations were further verified. Our results extend the until now modest number of studies investigating mtDNAcn and TL simultaneously in humans. In addition, we are the first to examine the relationship between mtDNAcn and telomere length in MZ and DZ twin subjects.
dc.description.urihttps://www.termedia.pl/Positive-association-and-future-perspectives-of-mitochondrial-DNA-copy-number-and-telomere-length-a-pilot-twin-study,19,35918,0,1.html
dc.language.isoeng
dc.publisherAMS, Archives of Medical Science
dc.titlePositive association and future perspectives of mitochondrial DNA copy number and telomere length – a pilot twin study
dc.typeJournal article
dc.source.journaltitleArchives of Medical Science
dc.source.spage1191
dc.source.epage1199
refterms.dateFOA2022-03-29T09:33:51Z
dc.publisher.placeWarsaw
dc.contributor.unitDepartment of Political Science
dc.identifier.urlhttps://www.termedia.pl/Positive-association-and-future-perspectives-of-mitochondrial-DNA-copy-number-and-telomere-length-a-pilot-twin-study,19,35918,0,1.html


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