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Genetic and environmental factors on the relation of lung function and arterial stiffness
Title / Series / Name
Respiratory Medicine
Publication Volume
107
Publication Issue
6
Pages
Authors
Tárnoki, Dávid László
Tárnoki, Ádám Domonkos
Lázár, Zsófia
Medda, Emanuela
Littvay, Levente
Cotichini, Rodolfo
Fagnani, Corrado
Stazi, Maria Antonietta
Nistico, Lorenza
Lucatelli, Pierleone
Boatta, Emanuele
Zini, Chiara
Fanelli, Fabrizio
Baracchini, Claudio
Meneghetti, Giorgio
Jermendy, György
Préda, István
Kiss, Róbert Gábor
Karlinger, Kinga
Lannert, Ágnes
Schillaci, Giuseppe
Molnár, Andrea Ágnes
Garami, Zsolt
Bérczi, Viktor
Horváth, Ildikó
Tárnoki, Ádám Domonkos
Lázár, Zsófia
Medda, Emanuela
Littvay, Levente
Cotichini, Rodolfo
Fagnani, Corrado
Stazi, Maria Antonietta
Nistico, Lorenza
Lucatelli, Pierleone
Boatta, Emanuele
Zini, Chiara
Fanelli, Fabrizio
Baracchini, Claudio
Meneghetti, Giorgio
Jermendy, György
Préda, István
Kiss, Róbert Gábor
Karlinger, Kinga
Lannert, Ágnes
Schillaci, Giuseppe
Molnár, Andrea Ágnes
Garami, Zsolt
Bérczi, Viktor
Horváth, Ildikó
Editors
Keywords
URI
https://hdl.handle.net/20.500.14018/13249
Abstract
An association between reduced lung function and increased cardiovascular risk has been reported, but the underlying mechanisms are unknown. The aim of this study was to assess the heritability of lung function and to estimate its genetic association with arterial stiffness. 150 monozygotic and 42 dizygotic healthy Hungarian and American Caucasian twin pairs (age 43 ± 17 years) underwent spirometry (forced vital capacity/FVC/, forced expiratory volume in 1 s/FEV1/; MIR Minispir, USA); and their brachial and central augmentation indices (AIx), and aortic pulse wave velocity (PWV) were measured by oscillometric Arteriograph (TensioMed Ltd, Budapest, Hungary). Phenotypic correlations and bivariate Cholesky decomposition models were applied. Age-, sex-, country- and smoking-adjusted heritability of FEV1, percent predicted FEV1, FVC and percent predicted FVC were 73% (95% confidence interval /CI/: 45–85%), 28% (95% CI: 0–67%), 68% (95% CI: 20–81%) and 45% (95% CI: 0–66%), respectively. Measured and percent predicted FVC and FEV1 values showed no significant phenotypic correlations with AIx or aortic PWV, except for phenotypic twin correlations between measured FEV1, FVC with brachial or aortic augmentation indices which ranged between −0.12 and −0.17. No genetic covariance between lung function and arterial stiffness was found. Lung function is heritable and the measured FVC and FEV are phenotypically, but not genetically, associated with augmentation index, a measure of wave reflection. This relationship may in turn reveal further associations leading to a better mechanistic understanding of vascular changes in various airway diseases.
Topic
Publisher
Place of Publication
Type
Journal article
Date
2013
Language
ISBN
Identifiers
https://doi.org/10.1016/j.rmed.2013.02.002