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dc.contributor.authorBernacchia, Alberto
dc.contributor.authorFiser, József
dc.contributor.authorHennequin, Guillaume
dc.contributor.authorLengyel, Máté
dc.date.accessioned2023-08-11T10:01:14Z
dc.date.available2023-08-11T10:01:14Z
dc.date.issued2022
dc.identifier.issn0896-6273
dc.identifier.doi10.1016/j.neuron.2022.03.006
dc.identifier.urihttp://hdl.handle.net/20.500.14018/14092
dc.description.abstractSequential activity reflecting previously experienced temporal sequences is considered a hallmark of learning across cortical areas. However, it is unknown how cortical circuits avoid the converse problem: producing spurious sequences that are not reflecting sequences in their inputs. We develop methods to quantify and study sequentiality in neural responses. We show that recurrent circuit responses generally include spurious sequences, which are specifically prevented in circuits that obey two widely known features of cortical microcircuit organization: Dale’s law and Hebbian connectivity. In particular, spike-timing-dependent plasticity in excitation-inhibition networks leads to an adaptive erasure of spurious sequences. We tested our theory in multielectrode recordings from the visual cortex of awake ferrets. Although responses to natural stimuli were largely non-sequential, responses to artificial stimuli initially included spurious sequences, which diminished over extended exposure. These results reveal an unexpected role for Hebbian experience-dependent plasticity and Dale’s law in sensory cortical circuits.
dc.language.isoengen_US
dc.publisherElsevier BVen_US
dc.rightsCC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCortical circuitsen_US
dc.subjectNeural dynamicsen_US
dc.subjectHebbian plasticityen_US
dc.subjectExcitation/inhibitionen_US
dc.subjectDale's lawen_US
dc.subjectSequential activityen_US
dc.subjectStatistical adaptationen_US
dc.titleAdaptive erasure of spurious sequences in sensory cortical circuitsen_US
dc.typeJournal article
dc.source.journaltitleNeuron
dc.source.volume110
dc.source.issue11
dc.source.spage1857
dc.source.epage1868
dc.description.versionPublished version
refterms.dateFOA2023-08-12T01:45:07Z


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