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dc.contributor.authorTárnoki, Ádám Domonkos
dc.contributor.authorTárnoki, Dávid László
dc.contributor.authorSpeer, Gábor
dc.contributor.authorLittvay, Levente
dc.contributor.authorBata, Pál
dc.contributor.authorGarami, Zsolt
dc.contributor.authorBérczi, Viktor
dc.contributor.authorKarlinger, Kinga
dc.date.available2022-03-29T09:33:54Z
dc.date.issued2015
dc.identifier.doihttp://dx.doi.org/10.1590/2359-3997000000110
dc.identifier.urihttp://hdl.handle.net/20.500.14018/13394
dc.description.abstractDecreased thyroid volume has been related to increased prevalence of thyroid cancer. One hundred and fourteen Hungarian adult twin pairs (69 monozygotic, 45 dizygotic) with or without known thyroid disorders underwent thyroid ultrasound. Thickness of the thyroid isthmus was measured at the thickest portion of the gland in the midline using electronic calipers at the time of scanning. Volume of the thyroid lobe was computed according to the following formula: thyroid height*width*depth*correction factor (0.63). Age-, sex-, body mass index- and smoking-adjusted heritability of the thickness of thyroid isthmus was 50% (95% confidence interval [CI], 35 to 66%). Neither left nor right thyroid volume showed additive genetic effects, but shared environments were 68% (95% CI, 48 to 80%) and 79% (95% CI, 72 to 87%), respectively. Magnitudes of monozygotic and dizygotic co-twin correlations were not substantially impacted by the correction of covariates of body mass index and smoking. Unshared environmental effects showed a moderate influence on dependent parameters (24-50%). Our analysis support that familial factors are important for thyroid measures in a general twin population. A larger sample size is needed to show whether this is because of common environmental (e.g. intrauterine effects, regional nutrition habits, iodine supply) or genetic effects.
dc.description.urihttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015005000110&lng=en&nrm=iso&tlng=en
dc.language.isoeng
dc.titleGenetic and environmental influence on thyroid gland volume and thickness of thyroid isthmus: a twin study
dc.typeJournal article
dc.source.journaltitleArchives of Endocrinology and Metabolism
dc.source.volume59
dc.source.issue6
dc.source.spage487
dc.source.epage494
refterms.dateFOA2022-03-29T09:33:55Z
dc.contributor.unitDepartment of Political Science
dc.source.journalabbrevArch. Endocrinol. Metab.
dc.identifier.urlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015005000110&lng=en&nrm=iso&tlng=en


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